卵巢两性母细胞瘤一例并文献复习
Ovarian gynandroblastoma:report of a case and literature review
田亚玲 1王玥元 1赵洁 1孙建平 1田芳1
作者信息
- 1. 甘肃省妇幼保健院病理科,兰州 730050
- 折叠
摘要
目的 探讨卵巢两性母细胞瘤(ovarian gynandroblastoma,GA)临床病理特征、鉴别诊断及治疗,为病理诊断和临床治疗提供依据.方法 回顾性分析1例卵巢两性母细胞瘤的临床病理特征及免疫组织化学表型,并对国内外相关文献进行复习.结果 大体标本呈灰黄色乳头状突起,质脆;HE染色见成人型颗粒细胞瘤和支持-间质细胞肿瘤成分;免疫组织化学结果显示calretinin、inhibin α、vimentin呈阳性,CK8/18呈部分阳性,网状纤维染色显示瘤细胞巢周围阳性,MC、CA199、EMA、CKP呈阴性表达,Ki-67增殖指数约10%.结论 卵巢两性母细胞瘤是一种十分罕见的卵巢性索-间质肿瘤,其诊断依赖于临床表现、HE染色检测及免疫组织化学分析,治疗方法以手术切除为主.
Abstract
Objective To discuss the clinicopathological characteristics,differential diagnosis,and treatment of ovarian gynan-droblastoma(GA),and to provide evidence for pathological diagnosis and clinical treatment.Methods A retrospective analysis of the clinicopathological features and immunohistochemical phenotype of one case of ovarian GA was conducted,along with a review of related literature domestically and internationally.Results The gross specimen presented as gray-yellow papillary protrusions with a brittle texture.HE staining showed components of adult-type granulosa cell tumor and stromal-supportive cell tumor.Immunohisto-chemistry revealed positive staining for calretinin,inhibin α,and vimentin,partial positivity for CK8/18,positive staining around tumor cell nests with reticular fiber staining,and negative expression for MC,CA199,EMA,and CKP.The Ki-67 proliferation index was approximately 10%.Conclusion Ovarian GA is a very rare ovarian sex cord-stromal tumor.Its diagnosis depends on clinical manifes-tations,HE staining,and immunohistochemical analysis.The primary treatment method is surgical resection.
关键词
两性母细胞瘤/卵巢/鉴别诊断Key words
Gynandroblastoma/ovary/differential diagnosis引用本文复制引用
基金项目
兰州市科技发展指导性计划项目(2019-ZD-127)
出版年
2024
NETL
NSTL
万方数据