幽门螺杆菌致病机制的多角度分析:毒力因子及外泌体
Multidimensional analysis of the pathogenesis of Helicobacter pylori infection:virulence factors and exosomes
王航宇 1刘琳琳 2向淼 2周佳琪 3孙圣林 4李盼盼 1王红艳1
作者信息
- 1. 山东省高等学校"免疫微环境与炎症性疾病研究特色实验室";基础医学院病原生物学教研室
- 2. 基础医学院病原生物学教研室
- 3. 公共卫生学院卫生毒理学实验室
- 4. 山东第二医科大学麻醉学院,潍坊 261021
- 折叠
摘要
幽门螺杆菌(Helicobacter pylori,H.pylori)是一种革兰氏阴性的微需氧菌,已被世界卫生组织(WHO)认定为I型致癌物,主要通过粪-口途径传播.幽门螺杆菌可通过黏附定植于胃黏膜上皮细胞引起慢性胃炎、胃溃疡、十二指肠溃疡以及胃癌等胃肠道疾病.幽门螺杆菌可通过多种复杂的机制逃避宿主的免疫防御从而长期定植于胃黏膜上皮细胞表面以及内部.目前关于幽门螺杆菌致病的详细机制尚未完全明了,本文从其毒力因子及外泌体对幽门螺杆菌作为始动因素诱导胃肠道疾病发生发展的机制进行综述,为幽门螺杆菌相关疾病的病因和防治提供了参考.
Abstract
Helicobacter pylori(H.pylori)is a Gram-negative microaerophilic bacterium recognized by the World Health Or-ganization(WHO)as a Group I carcinogen,primarily transmitted through the fecal-oral route.H.pylori can cause chronic gastritis,gastric ulcers,duodenal ulcers,and gastric cancer by adhering to and colonizing the epithelial cells of the gastric mucosa.Through various complex mechanisms,H.pylori can evade host immune defenses,leading to long-term colonization on the surface and within the epithelial cells of the gastric mucosa.Currently,the detailed mechanisms of H.pylori pathogenesis remain incompletely understood.This article reviews the virulence factors of H.pylori and the mechanisms by which its exosomes act as initiating factors in the devel-opment of gastrointestinal diseases,providing insights into the etiology and prevention of H.pylori-related diseases.
关键词
幽门螺杆菌/致病机制/胃炎/胃癌/毒力因子/外泌体Key words
Helicobacter pylori/pathogenesis of Helicobacter pylori infection/gastritis/gastric carcinoma/virulence factor/exosomes引用本文复制引用
基金项目
国家自然科学基金项目(81201262)
山东省自然基金项目(ZR2022MH172)
山东省自然基金项目(ZR2022QH165)
出版年
2024
NETL
NSTL
万方数据