The pathogenesis of ischemic stroke is complex,involving multiple pathological factors that contribute to its pro-gression and prognosis.Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α),a crucial nuclear transcription coacti-vator,effectively counteracts damage caused by ischemia and hypoxia,playing a pivotal regulatory role in ischemic stroke.Therefore,PGC-1α is considered a potential therapeutic target for ischemic stroke.This article reviews the research progress on the neuroprotec-tive mechanisms of PGC-1α in ischemic stroke,aiming to provide a theoretical basis for selecting drug treatment targets and offering a scientific reference for further studies.
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