弥漫性生长为主的滤泡性淋巴瘤伴1p36缺失8例临床病理学分析
Follicular lymphoma with a predominantly diffuse growth pattern with 1p36 deletion:a clinicopathologic analysis of eight cases
周军 1谢建兰 2周小鸽 2周晓军 3夏庆欣3
作者信息
- 1. 郑州大学附属肿瘤医院/河南省肿瘤医院病理科,郑州 450008;四川省自贡市第四人民医院病理科,自贡 643000
- 2. 首都医科大学附属北京友谊医院病理科,北京 100020
- 3. 郑州大学附属肿瘤医院/河南省肿瘤医院病理科,郑州 450008
- 折叠
摘要
目的 探讨弥漫性生长为主的滤泡性淋巴瘤(DFL)伴1p36缺失的临床病理特点.方法 收集2017年1月至2023年1月首都医科大学附属北京友谊医院(5例)和河南省肿瘤医院(3例)诊断为DFL伴1p36缺失病例的临床资料并随访,总结形态学特点,进行免疫标记和荧光原位杂交检测,结合文献和诊断经验进行讨论.结果 8例患者,男性5例,女性3例,中位年龄67岁,以腹股沟淋巴结肿大为主要特点.本组8例病理形态学基本类似,表现为正常淋巴结结构破坏,肿瘤以弥漫生长的中心样细胞增生为主,伴或不伴局灶滤泡性结构为特征.瘤细胞表达CD10和/或bcl-6等生发中心标志物,荧光原位杂交检测示1p36缺失但无bcl-2易位.结论 DFL伴1p36缺失是一组少见的滤泡性淋巴瘤亚型,病理学特点与其他类型的滤泡性淋巴瘤和低级别B细胞淋巴瘤存在一定程度的重叠;准确诊断需要结合临床特点、病理形态、免疫组织化学和相关分子检测进行综合判断.
Abstract
Objective To investigate the clinical and pathologic features and diagnosis of follicular lymphoma(FL)with a predominantly diffuse growth pattern(DFL)with 1p36 deletion.Methods Eight cases of DFL with 1p36 deletion diagnosed at Department of Pathology,Beijing Friendship Hospital,Capital Medical University(n=5)and the Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital(n=3)from January 2017 to January 2023 were included.Their clinicopathologic features and follow-up data were analyzed.Immunohistochemistry and fluorescence in situ hybridization(FISH)were performed.Results There were five males and three females,with a median age of 67 years,and inguinal lymphadenopathy was found as the main symptom.Histologically,similar morphologic features were sheared among all cases,with effaced nodal structure and characterized by proliferation of centrocytes in a diffuse pattern,with or without follicular components.The germinal center-related markers such as CD10 and/or bcl-6 were expressed in the tumor cells,and 1p36 deletion but not bcl-2 translocation was appreciable in these cases.Conclusions DFL with 1p36 deletion is a rare subtype of FL,with some overlaps with other types of FL or indolent B-cell lymphomas in their pathologic features.An accurate diagnosis requires comprehensive considerations based on their clinical,pathologic,immunohistochemical,and molecular features.
关键词
淋巴瘤,滤泡性/病理学,临床/诊断/癌基因Key words
Lymphoma,follicular/Pathology,clinical/Diagnosis/Oncogenes引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据