Follicular lymphoma with a predominantly diffuse growth pattern with 1p36 deletion:a clinicopathologic analysis of eight cases
Objective To investigate the clinical and pathologic features and diagnosis of follicular lymphoma(FL)with a predominantly diffuse growth pattern(DFL)with 1p36 deletion.Methods Eight cases of DFL with 1p36 deletion diagnosed at Department of Pathology,Beijing Friendship Hospital,Capital Medical University(n=5)and the Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital(n=3)from January 2017 to January 2023 were included.Their clinicopathologic features and follow-up data were analyzed.Immunohistochemistry and fluorescence in situ hybridization(FISH)were performed.Results There were five males and three females,with a median age of 67 years,and inguinal lymphadenopathy was found as the main symptom.Histologically,similar morphologic features were sheared among all cases,with effaced nodal structure and characterized by proliferation of centrocytes in a diffuse pattern,with or without follicular components.The germinal center-related markers such as CD10 and/or bcl-6 were expressed in the tumor cells,and 1p36 deletion but not bcl-2 translocation was appreciable in these cases.Conclusions DFL with 1p36 deletion is a rare subtype of FL,with some overlaps with other types of FL or indolent B-cell lymphomas in their pathologic features.An accurate diagnosis requires comprehensive considerations based on their clinical,pathologic,immunohistochemical,and molecular features.
NETL
NSTL
万方数据
维普
