首页|A novel, stable and reproducible acute lung injury model induced by oleic acid in immature piglet

A novel, stable and reproducible acute lung injury model induced by oleic acid in immature piglet

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
Background Young children are susceptible to pulmonary injury,and acute lung injury (ALl) often results in a high mortality and financial costs in pediatric patients.A good ALl model will help us to gain a better understanding of the real pathophysiological picture and to evaluate novel treatment approaches to acute respiratory distress syndrome (ARDS) more accurately and liberally.This study aimed to establish a hemodynamically stable and reproducible model with ALl in piglet induced by oleic acid.Methods Six Chinese mini-piglets were used to establish ALl models by oleic acid.Hemodynamic and pulmonary function data were measured.Histopathological assessment was performed.Results Mean blood pressure,heart rate (HR),cardiac output (CO),central venous pressure (CVP) and left atrial pressure (LAP) were sharply decreased after oleic acid given,while the mean pulmonary arterial pressure (MPAP) was increased in comparison with baseline (P ＜0.05).pH,arterial partial pressure of O2 (PaO2),PaO2/inspired O2 fraction (FiO2) and lung compliance decreased,while PaCO2 and airway pressure increased in comparison with baseline (P ＜0.05).The lung histology showed severe inflammation,hyaline membranes,intra-alveolar and interstitial hemorrhage.Conclusion This experiment established a stable model which allows for a diversity of studies on early lung injury.

acute respiratory distress syndromeoleic acidpigletsbolus injections

ZHU Yao-bin、LING Feng、ZHANG Yan-bo、LIU Ai-jun、LIU Dong-hai、QIAO Chen-hui、WANG Qiang、LIU Ying-long

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Department of Pediatric Heart Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China

Department of Pediatric Heart Center, Fuwal Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

Department of Cardiovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

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国家自然科学基金国家自然科学基金Beijing Municipal Education CommissionBeijing Municipal Education Commission

30670928No.81070055PXM2011_014226 07 000060Z11110006150000

2011

10.3760/cma.j.issn.0366-6999.2011.24.006

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCDCSCDSCI
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2011.124(24)
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