首页|γδT cells:Major advances in basic and clinical research in tumor immunotherapy

γδT cells:Major advances in basic and clinical research in tumor immunotherapy

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  • 国家科技期刊平台
  • NETL
  • NSTL
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γδ T cells are a kind of innate immune T cell.They have not attracted sufficient attention because they account for only a small proportion of all immune cells,and many basic factors related to these cells remain unclear.However,in recent years,with the rapid development of tumor immunotherapy,γδ T cells have attracted increasing attention because of their ability to exert cytotoxic effects on most tumor cells without major histocompatibility complex(MHC)restriction.An increasing number of basic studies have focused on the development,antigen recognition,activation,and antitumor immune response of γδT cells.Additionally,γδ T cell-based immunotherapeutic strategies are being developed,and the number of clinical trials investigating such strategies is increasing.This review mainly summarizes the progress of basic research and the clinical application of γδT cells in tumor immunotherapy to provide a theoretical basis for further the development of γδ T cell-based strategies in the future.

Gamma-delta T-cellsT cell receptorCD1aTumor immunotherapyReceptors,chimeric antigenVδ1 cellsαβ T cells

Yueqi Zhao、Peng Dong、Wei He、Jianmin Zhang、Hui Chen

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Department of Immunology,CAMS Key Laboratory for T Cell and Immunotherapy,State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and School of Basic Medicine,Peking Union Medical College,Beijing 100005,China

Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy,Changzhou,Jiangsu 213000,China

Haihe Laboratory of Cell Ecosystem,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300020,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaCAMS Initiative for Innovative MedicineCAMS Initiative for Innovative MedicineCAMS Initiative for Innovative MedicineHaihe Laboratory of Cell Ecosystem Innovation FundCAMS Central Public Welfare Scientific Research Institute Basal Research ExpensesChangzhou Science and Technology Support PlanBeijing Municipal Commission of Science and Technology Fund for Innovative Drug

322709153197084382071791U20A20374819728862022YFC36020042021-I2M-1-0052021-I2M-1-0352021-I2M-1-05322HHXBSS000283332020035CE20215008Z221100007922040

2024

10.1097/CM9.0000000000002781

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(1)
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