首页|Targeted therapies for lupus nephritis:Current perspectives and future directions

Targeted therapies for lupus nephritis:Current perspectives and future directions

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Lupus nephritis(LN),a severe manifestation of systemic lupus erythematosus,poses a substantial risk of progression to end-stage renal disease,with increased mortality.Conventional therapy for LN relies on broad-spectrum immunosuppressants such as glucocorticoids,mycophenolate mofetil,and calcineurin inhibitors.Although therapeutic regimens have evolved over the years,they have inherent limitations,including non-specific targeting,substantial adverse effects,high relapse rates,and pro-longed maintenance and remission courses.These drawbacks underscore the need for targeted therapeutic strategies for LN.Recent advancements in our understanding of LN pathogenesis have led to the identification of novel therapeutic targets and the emergence of biological agents and small-molecule inhibitors with improved specificity and reduced toxicity.This review pro-vides an overview of the current evidence on targeted therapies for LN,elucidates the biological mechanisms of responses and failure,highlights the challenges ahead,and outlines strategies for subsequent clinical trials and integrated immunomodulatory approaches.

Lupus nephritisMolecular targeted therapiesAdaptive immunityImmunity,InnateCytokines

Xiuzhi Jia、Yuewen Lu、Xunhua Zheng、Ruihan Tang、Wei Chen

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Department of Nephrology,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,Guangdong 510080,China

NHC Key Laboratory of Clinical Nephrology(Sun Yat-Sen University),and Guangdong Provincial Key Laboratory of Nephrology,Guangzhou,Guangdong 510080,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaKey Laboratory of National Health CommissionKey Laboratory of Nephrology,Guangdong Province,Guangzhou,ChinaKey Laboratory of Nephrology,Guangdong Province,Guangzhou,ChinaGuangdong Medical Science and Technology Research Fund Project of China

81970599821707372002B601182020B1212060028A2020085

2024

10.1097/CM9.0000000000002959

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(1)
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