首页|Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

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  • 国家科技期刊平台
  • NETL
  • NSTL
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Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the disease.In recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC phenotypes.Additionally,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the disease.Herein,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.

Small cell lung carcinomaMolecular classificationTumor heterogeneityDrug resistanceTranscription factorsGe-nomicsPhenotypePrognosis

Hanfei Guo、Wenqian Li、Ye Guo、Naifei Chen、Jiuwei Cui

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Cancer Center,The First Hospital of Jilin University,Changchun,Jilin 130021,China

Jilin Scientific and Technological Development Program(CN)General Program of National Natural Science Foundation of China

20190303146SF81874052

2024

10.1097/CM9.0000000000002693

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(2)
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