首页|Prognostic and clinical value of circPRKCI expression in diverse human cancers

Prognostic and clinical value of circPRKCI expression in diverse human cancers

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  • 国家科技期刊平台
  • NETL
  • NSTL
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Background:Highly expressed in various human cancers,circular RNA Protein Kinase C Iota(circPRKCI)has been reported to play an important role in cancer development and progression.Herein,we sought to reveal the prognostic and clinical value of circPRKCI expression in diverse human cancers.Methods:We searched the Pubmed,Web of Science,and the Cochrane Library databases from inception until May 16,2021.The relationship between circPRKCI expression and cancer patients'survival,including overall survival(OS)and disease-free survival(DFS),was assessed by pooled hazard ratios(HR)with corresponding 95％confidence interval(CI).The correlation between circPRKCI expression and clinical outcomes was evaluated using odds ratios(OR)with corresponding 95％CI.The data were analyzed by STATA software(version 12.0)or Review Manager(RevMan 5.3).Results:A total of 15 studies with 1109 patients were incorporated into our meta-analysis.The results demonstrated that high circPRKCI expression was significantly related to poor OS(HR=1.96,95％CI:1.61,2.39,P＜0.001)when compared with low circPRKCI expression in diverse human cancers.However,elevated circPRKCI expression was not associated with DFS(HR=1.34,95％CI:0.93,1.95,P=0.121).Furthermore,the patient with a higher circPRKCI expression was prone to have a larger tumor size,advanced clinical stage,and lymph node metastasis,but it was not significantly correlated with age,gender,and distant metastasis.Conclusion:Elevated circPRKCI expression was correlated with worse OS and unfavorable clinical features,suggesting a novel prognostic and predictive role of circPRKCI in diverse human cancers.

CircPRKCICancerPrognosisOverall survivalMeta-analysisCircular RNA Protein Kinase C Iota

Zhongyue Liu、Xiaolei Ren、Zhimin Yang、Lin Mei、Wenyi Li、Chao Tu、Zhihong Li

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Department of Orthopedics,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China

Hunan Key Laboratory of Tumor Models and Individualized Medicine,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaHunan Provincial Innovation Foundation for PostgraduateChina Postdoctoral Science Foundation

81902745821725008227266482103228CX201901602021M693557

2024

10.1097/CM9.0000000000002844

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(2)
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