首页|Aryl hydrocarbon receptor:Linking environment to aging process in elderly patients with asthma

Aryl hydrocarbon receptor:Linking environment to aging process in elderly patients with asthma

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  • 国家科技期刊平台
  • NETL
  • NSTL
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Aging is a significant risk factor for various diseases,including asthma,and it often leads to poorer clinical outcomes,particularly in elderly individuals.It is recognized that age-related diseases are due to a time-dependent accumulation of cellular damage,resulting in a progressive decline in cellular and physiological functions and an increased susceptibility to chronic diseases.The effects of aging affect not only the elderly but also those of younger ages,posing significant challenges to global healthcare.Thus,understanding the molecular mechanisms associated with aging in different diseases is essential.One intriguing factor is the aryl hydrocarbon receptor(AhR),which serves as a cytoplasmic receptor and ligand-activated transcription factor and has been linked to the aging process.Here,we review the literature on several major hallmarks of aging,including mitochondrial dysfunction,cellular senescence,autophagy,mitophagy,epigenetic alterations,and microbiome disturbances.Moreover,we provide an over-view of the impact of AhR on these hallmarks by mediating responses to environmental exposures,particularly in relation to the immune system.Furthermore,we explore how aging hallmarks affect clinical characteristics,inflammatory features,exacerba-tions,and the treatment of asthma.It is suggested that AhR signaling may potentially play a role in regulating asthma phenotypes in elderly populations as part of the aging process.

AgingEnvironmentReactive oxygen speciesSenescenceAryl hydrocarbon receptorAsthma

Tianrui Yang、Rongjun Wan、Wei Tu、Sai Nithin Awaru、Peisong Gao

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Division of Allergy and Clinical Immunology,Department of Medicine,Johns Hopkins University School of Medicine,Baltimore,MD 21224,USA

Department of Geriatric Medicine,The First People's Hospital of Yunnan Province,Kunming,Yunnan 650032,China

Department of Respiratory Medicine,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China

The State Key Laboratory of Respiratory Disease for Allergy,Shenzhen Key Laboratory of Allergy and Immunology,Shenzhen University School of Medicine,Shenzhen,Guangdong 518055,China

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US National Institutes of Health(NIH)US National Institutes of Health(NIH)Department of Science and Technology of Yunnan Province,China

1R01AI153331R01AI141642202201AY070001-260

2024

10.1097/CM9.0000000000002960

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(4)
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