首页|Hypertension and NAFLD risk:Insights from the NHANES 2017-2018 and Mendelian randomization analyses

Hypertension and NAFLD risk:Insights from the NHANES 2017-2018 and Mendelian randomization analyses

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Background:Hypertension and non-alcoholic fatty liver disease(NAFLD)share several pathophysiologic risk factors,and the exact relationship between the two remains unclear.Our study aims to provide evidence concerning the relationship between hypertension and NAFLD by analyzing data from the National Health and Nutrition Examination Survey(NHANES)2017-2018 and Mendelian randomization(MR)analyses.Methods:Weighted multivariable-adjusted logistic regression was applied to assess the relationship between hypertension and NAFLD risk by using data from the NHANES 2017-2018.Subsequently,a two-sample MR study was performed using the genome-wide association study(GWAS)summary statistics to identify the causal association between hypertension,systolic blood pressure(SBP),diastolic blood pressure(DBP),and NAFLD.The primary inverse variance weighted(IVW)and other supplementary MR approaches were conducted to verify the causal association between hypertension and NAFLD.Sensitivity analyses were adopted to confirm the robustness of the results.Results:A total of 3144 participants were enrolled for our observational study in NHANES.Weighted multivariable-adjusted logistic regression analysis suggested that hypertension was positively related to NAFLD risk(odds ratio[OR]=1.677;95％confidence interval[CI],1.159-2.423).SBP ≥130 mmHg and DBP ≥80 mmHg were also significantly positively correlated with NAFLD.Moreover,hypertension was independently connected with liver steatosis(β=7.836[95％CI,2.334-13.338]).The results of MR analysis also supported a causal association between hypertension(OR=7.203[95％CI,2.297-22.587])and NAFLD.Similar results were observed for the causal exploration between SBP(OR=1.024[95％CI,1.003-1.046]),DBP(OR=1.047[95％CI,1.005-1.090]),and NAFLD.The sensitive analysis further confirmed the robustness and reliability of these findings(all P＞0.05).Conclusion:Hypertension was associated with an increased risk of NAFLD.

HypertensionNon-alcoholic fatty liver diseaseNational Health and Nutrition Examination SurveyMendelian ran-domization analysisCausality

Mengqin Yuan、Jian He、Xue Hu、Lichao Yao、Ping Chen、Zheng Wang、Pingji Liu、Zhiyu Xiong、Yingan Jiang、Lanjuan Li

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Department of Infectious Diseases,Renmin Hospital of Wuhan University,Wuhan,Hubei 430000,China

Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510010,China

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Centre for Infectious Diseases,Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases,Department of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,Zhejiang 310000,China

Wuhan University Education & Development FoundationNational Stem Cell Clinical Research Project of China

2002330

2024

10.1097/CM9.0000000000002753

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(4)
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