首页|Metabolic plasticity of T cell fate decision

Metabolic plasticity of T cell fate decision

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of the T cells.Upon antigen exposure,T cells undergo metabolic reprogramming,leading to the development of functional effectors or memory populations.However,within the tumor microenvironment(TME),metabolic stress impairs CD8+T cell anti-tumor immunity,resulting in exhausted dif-ferentiation.Recent studies suggested that targeting T cell metabolism could offer promising therapeutic opportunities to enhance T cell immunotherapy.In this review,we provide a comprehensive summary of the intrinsic and extrinsic factors necessary for metabolic reprogramming during the development of effector and memory T cells in response to acute and chronic inflammatory conditions.Furthermore,we delved into the different metabolic switches that occur during T cell exhaustion,exploring how prolonged metabolic stress within the TME triggers alterations in cellular metabolism and the epigenetic landscape that contribute to T cell exhaustion,ultimately leading to a persistently exhausted state.Understanding the intricate relationship between T cell metabolism and cancer immunotherapy can lead to the development of novel approaches to improve the efficacy of T cell-based treatments against cancer.

T cell immunotherapyT cell differentiationT cell exhaustionMetabolic reprogrammingTumor microenvironment

Xiaoli Pan、Jiajia Wang、Lianjun Zhang、Guideng Li、Bo Huang

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National Key Laboratory of Immunity and Inflammation,Suzhou Institute of Systems Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Suzhou,Jiangsu 215123,China

Key Laboratory of Synthetic Biology Regulatory Element,Suzhou Institute of Systems Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Suzhou,Jiangsu 215123,China

Department of Immunology & National Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences(CAMS)& Peking Union Medical College,Beijing 100005,China

Department of Biochemistry & Molecular Biology,Tongji Medical College,Huazhong University of Science & Technology,Wuhan,Hubei 430030,China

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国家自然科学基金国家自然科学基金国家自然科学基金Chinese Academy of Medical Sciences Innovation Fund for Medical SciencesChinese Academy of Medical Sciences Innovation Fund for Medical SciencesChinese Academy of Medical Sciences Innovation Fund for Medical SciencesHaihe Laboratory of Cell Ecosystem Innovation Fund江苏省自然科学基金优秀青年基金江苏省自然科学基金优秀青年基金

8178810182271775819728752021-I2M-1-0212021-I2M-1-0612022-I2M-1-04722HHXBSS00009BK20220049BK20211505

2024

10.1097/CM9.0000000000002989

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(7)
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