首页|Targeting metabolism to improve CAR-T cells therapeutic efficacy

Targeting metabolism to improve CAR-T cells therapeutic efficacy

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Chimeric antigen receptor T(CAR-T)cell therapy achieved advanced progress in the treatment of hematological tumors.However,the application of CAR-T cell therapy for solid tumors still faces many challenges.Competition with tumor cells for metabolic resources in an already nutrient-poor tumor microenvironment is a major contributing cause to CAR-T cell therapy's low effec-tiveness.Abnormal metabolic processes are now acknowledged to shape the tumor microenvironment,which is characterized by increased interstitial fluid pressure,low pH level,hypoxia,accumulation of immunosuppressive metabolites,and mitochondrial dysfunction.These factors are important contributors to restriction of T cell proliferation,cytokine release,and suppression of tumor cell-killing ability.This review provides an overview of how different metabolites regulate T cell activity,analyzes the current dilemmas,and proposes key strategies to reestablish the CAR-T cell therapy's effectiveness through targeting metabolism,with the aim of providing new strategies to surmount the obstacle in the way of solid tumor CAR-T cell treatment.

CAR-T cell therapyMetabolismTumor microenvironmentImmunotherapyMitochondrial fitness

Shasha Liu、Yuyu Zhao、Yaoxin Gao、Feng Li、Yi Zhang

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Biotherapy Center and Cancer Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China

School of Life Sciences,Zhengzhou University,Zhengzhou,Henan 450052,China

Engineering Key Laboratory for Cell Therapy of Henan Province,Zhengzhou,Henan 450052,China

School of Public Health,Zhengzhou University,Zhengzhou,Henan 450000,China

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National Key Research and Development Program Intergovernmental Key Project for International Science and Technology Innovation Natural Science Foundation of ChinaChina Postdoctoral Science Foundation ProjectMedical Science and Technology Project of Henan ProvinceMajor science and technology project of Henan Province

2022YFE0141000822035482022M712894LHGJ20220385221100310100

2024

10.1097/CM9.0000000000003046

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(8)
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