首页|Caloric restriction,Sirtuins,and cardiovascular diseases

Caloric restriction,Sirtuins,and cardiovascular diseases

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Caloric restriction(CR)is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases,including cardiovascular conditions.Sirtuins,a family of nicotinamide adenine dinucleotide(NAD+)-depen-dent histone deacetylases,have emerged as key regulators of cellular metabolism,stress responses,and the aging process,serving as energy status sensors in response to CR.However,the mechanism through which CR regulates Sirtuin function to ameliorate cardiovascular disease remains unclear.This review not only provided an overview of recent research investigating the interplay between Sirtuins and CR,specifically focusing on their potential implications for cardiovascular health,but also provided a comprehensive summary of the benefits of CR for the cardiovascular system mediated directly via Sirtuins.CR has also been shown to have considerable impact on specific metabolic organs,leading to the production of small molecules that enter systemic circulation and subsequently regulate Sirtuin activity within the cardiovascular system.The direct and indirect effects of CR offer a potential mechanism for Sirtuin modulation and subsequent cardiovascular protection.Understanding the interplay between CR and Sirtuins will provide new insights for the development of interventions to prevent and treat cardiovascular diseases.

Caloric restrictionSirtuinsCardiovascular diseasesHealthy lifestyleDietary

Ziyu Wei、Bo Yang、Huiyu Wang、Shuangjie Lv、Houzao Chen、Depei Liu

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State Key Laboratory of Common Mechanism Research for Major Diseases,Department of Biochemistry and Molecular Biology,Institute of Basic Medical Sciences,Chinese Acade-my of Medical Sciences & Peking Union Medical College,Beijing 100005,China

National Key Research and Development Project of ChinaNational Key Research and Development Project of ChinaNational Key Research and Development Project of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChinese Academy of Medical Sciences Innovation Fund for Medical SciencesChinese Academy of Medical Sciences Innovation Fund for Medical SciencesChinese Academy of Medical Sciences Innovation Fund for Medical Sciences

2020YFC20080032021YFA08049002019YFA08015009214930582225007820300172021-I2M-1-0162022-I2M-JB-0062022-I2M-2-002

2024

10.1097/CM9.0000000000003056

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(8)
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