首页|Mitochondrial energy metabolism in diabetic cardiomyopathy:Physiological adaption,pathogenesis,and therapeutic targets

Mitochondrial energy metabolism in diabetic cardiomyopathy:Physiological adaption,pathogenesis,and therapeutic targets

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the patients.Although blood glucose control and medications to heart failure show beneficial effects on this disease,there is currently no specific treatment for diabetic cardiomyopathy.Over the past few decades,the pathophysiology of diabetic cardiomyopathy has been extensively studied,and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic target.In this review,we summarize the latest research in the field of diabetic cardiomyopathy,focusing on mitochondrial damage and adaptation,altered energy substrates,and potential therapeutic targets.A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.

MitochondriaMitochondrial energy metabolismDiabetic cardiomyopathiesPhysiologyPhysiological adaptionPathogenesisTherapeutics

Wanlin Ye、Kun Han、Maodi Xie、Sheyu Li、Guo Chen、Yanyan Wang、Tao Li

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Department of Anesthesiology,Laboratory of Mitochondria and Metabolism,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Department of Anesthesiology,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu,Sichuan 610041,China

Department of Endocrinology and Metabolism,Division of Guideline and Rapid Recommendation,Cochrane China Center,MAGIC China Center,Chinese Evidence-Based Medicine Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Nursing Key Laboratory of Sichuan Province,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

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Yunnan Provincial Cardiovascular Disease Clinical Medical Center ProjectYunnan Provincial Cardiovascular Disease Clinical Medical Center ProjectKey Research and Development Program of Sichuan ProvinceKey Research and Development Program of Sichuan ProvinceKey Research and Development Program of Sichuan ProvinceNational Natural Science Foundation of ChinaNational Natural Science Foundation of China

FZX2019-06-012022YFKY0782022YFS01322022YFS01982023YFS02958197071582370260

2024

10.1097/CM9.0000000000003075

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(8)
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