首页|Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications

Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Metastasis-associated lung adenocarcinoma transcript 1(MALAT1)is a well-established oncogenic long non-coding RNA,the higher expression of which is strongly correlated with cancer events such as tumorigenesis,progression,metastasis,drug resistance,and treatment outcome in solid cancers.Recently,a series of studies has highlighted its potential role in hematological malig-nancies in terms of these events.Similar to solid cancers,MALAT1 can regulate various target genes via sponging and epigenetic mechanisms,but the miRNAs sponged by MALAT1 differ from those identified in solid cancers.In this review,we systematically describe the role and underlying mechanisms of MALAT1 in multiple types of hematological malignancies,including regulation of cell proliferation,metastasis,stress response,and glycolysis.Clinically,MALAT1 expression is related to poor treatment outcome and drug resistance,therefore exhibiting potential prognostic value in multiple myeloma,lymphoma,and leukemia.Finally,we discuss the evaluation of MALAT1 as a novel therapeutic target against cancer in preclinical studies.

Long non-coding RNAMALAT1Hematological malignanciesTumorigenesisMetastasisDrug resistancePrognostic biomarker

Chunlan Zhang、Yun Qin、Yu Wu、Heng Xu、Yang Shu

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Department of Hematology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Department of Radiology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Department of Laboratory Medicine/Research Center of Clinical Laboratory Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Department of Biotherapy,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Institute of General Surgery,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Department of General Surgery,Gastric Cancer Center and Laboratory of Gastric Cancer,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

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国家自然科学基金国家自然科学基金1.3.5 Project for Disciplines of Excellence,West China Hospital,and Sichuan University

8197340882273445ZYYC20003

2024

10.1097/CM9.0000000000003090

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(10)
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