首页|Birth weight,ideal cardiovascular health metrics in adulthood,and incident cardiovascular disease

Birth weight,ideal cardiovascular health metrics in adulthood,and incident cardiovascular disease

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  • 国家科技期刊平台
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  • NSTL
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Background:Prenatal and postnatal factors may have joint effects on cardiovascular health,and we aimed to assess the joint association of birth weight and ideal cardiovascular health metrics(ICVHMs)prospectively in adulthood with incident cardio-vascular disease(CVD).Methods:In the UK Biobank,227,833 participants with data on ICVHM components and birth weight and without CVD at baseline were included.The ICVHMs included smoking,body mass index,physical activity,diet information,total cholesterol,blood pressure,and hemoglobin A1c.The Cox proportional hazards model was used to estimate the hazard ratios(HRs)and 95％confidence intervals(CIs)in men and women.Results:Over a median follow-up period of 13.0 years(2,831,236 person-years),we documented 17,477 patients with incident CVD.Compared with participants with birth weights of 2.5-4.0 kg,the HRs(95％CIs)of CVD among those with low birth weights was 1.08(1.00-1.16)in men and 1.23(1.16-1.31)in women.The association between having a birth weight＜2.5 kg and CVD risk in men was more prominent for those aged＜50 years than for those of older age(P for interaction=0.026).Lower birth weight and non-ideal cardiovascular health metrics were jointly related to an increased risk of CVD.Participants with birth weights＜2.5 kg and ICVHMs score 0-1 had the highest risk of incident CVD(HR[95％CI]:3.93[3.01-5.13]in men;4.24[3.33-5.40]in women).The joint effect(HR[95％CI]:1.36[1.17-1.58])could be decomposed into 24.7％(95％CI:15.0％-34.4％)for a lower birth weight,64.7％(95％CI:56.7％-72.6％)for a lower ICVHM score,and 10.6％(95％CI:2.7％-18.6％)for their additive interaction in women.Conclusions:Birth weight and ICVHMs were jointly related to CVD risk.Attaining a normal birth weight and ideal ICVHMs may reduce the risk of CVD,and a simultaneous improvement of both prenatal and postnatal factors could further prevent additional cases in women.

Birth weightHealth metricsCardiovascular diseaseAdultStrokeCoronary heart disease

Ying Sun、Bin Wang、Yuefeng Yu、Yuying Wang、Xiao Tan、Jihui Zhang、Lu Qi、Yingli Lu、Ningjian Wang

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Department of Endocrinology and Metabolism,Institute of Endocrinology and Metabolism,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

School of Public Health,Zhejiang University,Hangzhou,Zhejiang 310058,China

Department of Medical Sciences,Uppsala University,Uppsala 75105,Sweden

Center for Sleep and Circadian Medicine,The Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510370,China

Department of Epidemiology,School of Public Health and Tropical Medicine,Tulane University,New Orleans,LA 70118,USA

Department of Nutrition,Harvard T.H.Chan School of Public Health,Boston,MA 02138,USA

Channing Division of Network Medicine,Department of Medicine,Brigham and Women's Hospital and Harvard Medical School,Boston,MA 02138,USA

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国家自然科学基金上海市科委项目上海市人社局项目Clinical Research Plan of SHDCShanghai Ninth People's Hospital

82170870191409024002020074SHDC2020CR4006YBKB202218

2024

10.1097/CM9.0000000000003043

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(10)
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