The Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE,State Key Laboratory of Biotherapy,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Department of Nephrology,Henan Provincial Clinical Research Center for Kidney Disease,Henan Provincial Key Laboratory of Kidney Disease and Immunology,Henan Provincial People's Hospital and People's Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China

Department of Biochemistry,School of Medicine,Case Western Reserve University,Cleveland,OH 44106,USA

Center for RNA Science and Therapeutics,School of Medicine,Case Western Reserve University,Cleveland,OH 44106,USA

Department of Pulmonary and Critical Care Medicine,Chengdu First People's Hospital,Chengdu,Sichuan 610095,China