首页|The switch triggering the invasion process:Lipid metabolism in the metastasis of hepatocellular carcinoma
The switch triggering the invasion process:Lipid metabolism in the metastasis of hepatocellular carcinoma
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
国家科技期刊平台
NETL
NSTL
万方数据
In humans,the liver is a central metabolic organ with a complex and unique histological microenvironment.Hepatocellular car-cinoma(HCC),which is a highly aggressive disease with a poor prognosis,accounts for most cases of primary liver cancer.As an emerging hallmark of cancers,metabolic reprogramming acts as a runaway mechanism that disrupts homeostasis of the affected organs,including the liver.Specifically,rewiring of the liver metabolic microenvironment,including lipid metabolism,is driven by HCC cells,propelling the phenotypes of HCC cells,including dissemination,invasion,and even metastasis in return.The resulting formation of this vicious loop facilitates various malignant behaviors of HCC further.However,few articles have comprehensively summarized lipid reprogramming in HCC metastasis.Here,we have reviewed the general situation of the liver microenvironment and the physiological lipid metabolism in the liver,and highlighted the effects of different aspects of lipid metabolism on HCC metastasis to explore the underlying mechanisms.In addition,we have recapitulated promising therapeutic strategies targeting lipid metabolism and the effects of lipid metabolic reprogramming on the efficacy of HCC systematical therapy,aiming to offer new perspectives for targeted therapy.
Department of Gastroenterology,Institute of Liver and Gastrointestinal Diseases,Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases,Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi'an,Shaanxi 710032,China
National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Hubei ProvinceBasic Research Support Program of Huazhong University of Science and Technology
国家科技期刊平台
NSTL
万方数据
