首页|Hematopoietic aging:Cellular,molecular,and related mechanisms

Hematopoietic aging:Cellular,molecular,and related mechanisms

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Aging is accompanied by significant inhibition of hematopoietic and immune system function and disruption of bone marrow structure.Aging-related alterations in the inflammatory response,immunity,and stem cell niches are at the root of hematopoietic aging.Understanding the molecular mechanisms underlying hematopoietic and bone marrow aging can aid the clinical treatment of aging-related diseases.In particular,it is unknown how the niche reprograms hematopoietic stem cells(HSCs)in an age-dependent manner to maintain normal hematopoiesis in elderly individuals.Recently,specific inhibitors and blood exchange methods have been shown to reshape the hematopoietic niche and reverse hematopoietic aging.Here,we present the latest scientific discoveries related to hematopoietic aging and hematopoietic system rejuvenation,discuss the relationships between hematopoietic niche aging and HSC aging,and describe related studies on stem cell-mediated regulation of hematopoietic aging,aiming to provide new ideas for further study.

Stem cellsHematopoietic stem cellNicheHematopoietic aging

Li Ye、Chuan Tian、Ye Li、Hang Pan、Jinxiu Hu、Liping Shu、Xinghua Pan

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The Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions,Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province,Kunming Key Laboratory of Stem Cell and Regenerative Medicine,Basic Medical Laboratory,920th Hospital of Joint Logistics Support Force,PLA,Kunming,Yunnan 650032,China

Department of Immunology of School of Basic Medicine of Guizhou Medical University,National and Local Joint Engineering Laboratory of Cell Engineering Biomedical

Department of Immunology of School of Basic Medicine of Guizhou Medical University,National and Local Joint Engineering Laboratory of Cell Engineering Biomedical Technology,Key Laboratory of Regenerative Medicine of Guizhou Province,State Key Laboratory of Efficacy and Utilization of Medicinal Plants Co-constructed by Province and Ministry,Key Laboratory of Translational Research of Adult Stem Cell of Chinese Academy of Medical Sciences,Guiyang,Guizhou 550025,China

Yunnan Science and Technology Plan Project Major Science and Technology Projectproject entitled efficacy and mechanism of mesenchymal stem cell therapy based on ovarian aging tree shrew model

2018ZF007SYDW_KY[2021]18

2024

10.1097/CM9.0000000000002871

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(11)
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