首页|Role of triggering receptor expressed on myeloid cells-1 in kidney diseases:A biomarker and potential therapeutic target

Role of triggering receptor expressed on myeloid cells-1 in kidney diseases:A biomarker and potential therapeutic target

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  • 国家科技期刊平台
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Triggering receptor expressed on myeloid cells-1(TREM-1)is a member of the immunoglobulin superfamily.As an amplifier of the inflammatory response,TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival.TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders.More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases.There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease.This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury,renal fibrosis,diabetic nephropathy,immune nephropathy,and renal cell carcinoma.

TREM-1Kidney diseasesInflammatory responseBiomarkerTherapeutic targets

Yuxi Fan、Ye Xu、Zhi Huo、Hedong Zhang、Longkai Peng、Xin Jiang、Angus W.Thomson、Helong Dai

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Department of Immunology,School of Basic Medical Science,Central South University,Changsha,Hunan 410013,China

Department of Kidney Transplantation,Center of Organ Transplantation,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China

Medical College of Guangxi University,Nanning,Guangxi 530004,China

Department of Organ Transplantation,The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People's Hospital),Zhengzhou,Henan 450000,China

Department of Surgery,Thomas E.Starzl Transplantation Institute,University of Pittsburgh School of Medicine,Pittsburgh,PA 15261,USA

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience and Technology Innovation Program of Hunan ProvinceNatural Science Foundation of Hunan ProvinceHigher Education Teaching Reform Project of Central South University

820707768227079682200849823707612022RC30712023JJ408722023jy110

2024

10.1097/CM9.0000000000003197

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(14)
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