首页|A systematic review of the role of TREM2 in Alzheimer's disease

A systematic review of the role of TREM2 in Alzheimer's disease

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Background:Given the established genetic linkage between triggering receptors expressed on myeloid cells 2(TREM2)and Alzheimer's disease(AD),an expanding research body has delved into the intricate role of TREM2 within the AD context.However,a conflicting landscape of outcomes has emerged from both in vivo and in vitro investigations.This study aimed to elucidate the multifaceted nuances and gain a clearer comprehension of the role of TREM2.Methods:PubMed database was searched spanning from its inception to January 2022.The search criteria took the form of("Alzheimer's disease"OR"AD")AND("transgenic mice model"OR"transgenic mouse model")AND("Triggering receptor expressed on myeloid cells"OR"TREM2").Inclusion criteria consisted of the following:(1)publication of original studies in English;(2)utilization of transgenic mouse models for AD research;and(3)reports addressing the subject of TREM2.Results:A total of 43 eligible articles were identified.Our analysis addresses four pivotal queries concerning the interrelation of TREM2 with microglial function,Aβ accumulation,tau pathology,and inflammatory processes.However,the diverse inquiries posed yielded inconsistent responses.Nevertheless,the inconsistent roles of TREM2 within these AD mouse models potentially hinge upon factors such as age,sex,brain region,model type,and detection methodologies.Conclusions:This review substantiates the evolving understanding of TREM2's disease progression-dependent impacts.Further-more,it reviews the interplay between TREM2 and its effects across diverse tissues and temporal stages.

TREM2Alzheimer's diseaseMouse modelMicrogliaAmyloid-β accumulationTau pathologyInflammation

Yunsi Yin、Hanchen Yang、Ruiyang Li、Guangshan Wu、Qi Qin、Yi Tang

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Department of Neurology & Innovation Center for Neurological Disorders,Xuanwu Hospital,Capital Medical University,National Center for Neurological Disorders,Beijing 100053,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaSTI2030-Major ProjectsYoung Elite Scientists Sponsorship Program by CASTBeijing Hospitals Authority Innovation Studio of Young Staff Funding SupportBeijing Nova Program

8222010800981970996822015682022YFC36026002021ZD02018012021QNRC001202118Z211100002121051

2024

10.1097/CM9.0000000000003000

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(14)
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