首页|Bioinformatic approaches of liquid-liquid phase separation in human disease
Bioinformatic approaches of liquid-liquid phase separation in human disease
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国家科技期刊平台
NETL
NSTL
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Biomolecular aggregation within cellular environments via liquid-liquid phase separation(LLPS)spontaneously forms drop-let-like structures,which play pivotal roles in diverse biological processes.These structures are closely associated with a range of diseases,including neurodegenerative disorders,cancer and infectious diseases,highlighting the significance of understanding LLPS mechanisms for elucidating disease pathogenesis,and exploring potential therapeutic interventions.In this review,we delineate recent advancements in LLPS research,emphasizing its pathological relevance,therapeutic considerations,and the pivotal role of bioinformatic tools and databases in facilitating LLPS investigations.Additionally,we undertook a comprehensive analysis of bioinformatic resources dedicated to LLPS research in order to elucidate their functionality and applicability.By providing comprehensive insights into current LLPS-related bioinformatics resources,this review highlights its implications for human health and disease.
Department of Thoracic Surgery and West China Biomedical Big Data Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China
Med-X Center for Informatics,Sichuan University,Chengdu,Sichuan 610041,China
Department of Orthognathic and TMJ Surgery,State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,Sichuan 610041,China
广东省自然科学基金Postdoctoral Fellowship Program of CPSF中国博士后科学基金国家自然科学基金青年基金国家自然科学基金
国家科技期刊平台
NSTL
万方数据
