首页|Association between coronary artery stenosis and myocardial injury in patients with acute pulmonary embolism:A case-control study

Association between coronary artery stenosis and myocardial injury in patients with acute pulmonary embolism:A case-control study

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  • 国家科技期刊平台
  • NETL
  • NSTL
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Background:The potential impact of pre-existing coronary artery stenosis(CAS)on acute pulmonary embolism(PE)episodes remains underexplored.This study aimed to investigate the association between pre-existing CAS and the elevation of high-sensi-tivity cardiac troponin Ⅰ(hs-cTnⅠ)levels in patients with PE.Methods:In this multicenter,prospective case-control study,88 cases and 163 controls matched for age,sex,and study center were enrolled.Cases were patients with PE with elevated hs-cTnⅠ.Controls were patients with PE with normal hs-cTnⅠ.Coronary artery assessment utilized coronary computed tomographic angiography or invasive coronary angiography.CAS was defined as≥50％stenosis of the lumen diameter in any coronary vessel＞2.0 mm in diameter.Conditional logistic regression was used to evaluate the association between CAS and hs-cTnⅠ elevation.Results:The percentage of CAS was higher in the case group compared to the control group(44.3％[39/88]vs.30.1％[49/163];P=0.024).In multivariable conditional logistic regression model 1,CAS(adjusted odds ratio[OR],2.680;95％confidence interval[CI],1.243-5.779),heart rate＞75 beats/min(OR,2.306;95％CI,1.056-5.036)and N-terminal pro-B type natriuretic peptide(NT-proBNP)＞420 pg/mL(OR,12.169;95％CI,4.792-30.900)were independently associated with elevated hs-cTnI.In model 2,right CAS(OR,3.615;95％CI,1.467-8.909)and NT-proBNP＞420 pg/mL(OR,13.890;95％CI,5.288-36.484)were independently associated with elevated hs-cTnⅠ.Conclusions:CAS was independently associated with myocardial injury in patients with PE.Vigilance towards CAS is warranted in patients with PE with elevated cardiac troponin levels.

Pulmonary embolismCoronary artery stenosisMyocardial injuryCardiac troponin ⅠMyocardial ischemiaRight ventricular dysfunctionCase-control studyCoronary computed tomography angiography

Yinjian Yang、Chao Liu、Jieling Ma、Xijie Zhu、Jingsi Ma、Dan Lu、Xinxin Yan、Xuan Gao、Jia Wang、Liting Wang、Sijin Zhang、Xianmei Li、Bingxiang Wu、Kai Sun、Yimin Mao、Xiqi Xu、Tianyu Lian、Chunyan Cheng、Zhicheng Jing

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Medical Science Research Center,Institute of Clinical Medicine,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou,Guangdong 510080,China

Department of Cardiology,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

Department of School of Pharmacy,Henan University,Kaifeng,Henan 475001,China

Cardiac Department,Aerospace Center Hospital,Peking University Aerospace School of Clinical Medicine,Beijing 100049,China

Department of Cardiology,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China

Department of Cardiovascular Medicine,The Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,China

Department of Medical Laboratory,Weifang Medical University,Weifang,Shandong 261053,China

Department of Respiratory Medicine,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471003,China

Center of Basic Medical Research,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou,Guangdong 510080,China

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国家重点研发计划National High Level Hospital Clinical Research FundingChinese Academy of Medical Sciences Innovation Fund for Medical SciencesChinese Academy of Medical Sciences Innovation Fund for Medical Sciences

2022YFC27039022022-PUMCH-B-0992020-I2M-C&T-B-0032021-I2M-1-018

2024

10.1097/CM9.0000000000003206

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(16)