首页|Tumor angiogenesis and anti-angiogenic therapy

Tumor angiogenesis and anti-angiogenic therapy

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Anti-angiogenic drugs(AADs),which mainly target the vascular endothelial growth factor-A signaling pathway,have become a therapeutic option for cancer patients for two decades.During this period,tremendous clinical experience of anti-angiogenic therapy has been acquired,new AADs have been developed,and the clinical indications for AAD treatment of various cancers have been expanded using monotherapy and combination therapy.However,improvements in the therapeutic outcomes of clini-cally available AADs and the development of more effective next-generation AADs are still urgently required.This review aims to provide historical and perspective views on tumor angiogenesis to allow readers to gain mechanistic insights and learn new therapeutic development.We revisit the history of concept initiation and AAD discovery,and summarize the up-to-date clinical translation of anti-angiogenic cancer therapy in this field.

AngiogenesisCancerAngiogenesis inhibitorsAngiogenic factorsVascular endothelial growth factorsCancer therapyCombined modality therapy

Ziheng Guo、Xu Jing、Xiaoting Sun、Shishuo Sun、Yunlong Yang、Yihai Cao

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Department of Pancreatic Surgery,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 17177, Sweden

Department of Microbiology,Tumor and Cell Biology,Karolinska Institute,Stockholm 17177,Sweden

ujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vison and Brain Health),School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,Zhejiang 325035,China

Cancer Institute,the First Clinical Medical College,Xuzhou Medical University,Xuzhou,Jiangsu 221000,China

Department of Cellular and Genetic Medicine,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China

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2024

10.1097/CM9.0000000000003231

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(17)