首页|Cerebellar involvement in Parkinson's disease:Pathophysiology and neuroimaging

Cerebellar involvement in Parkinson's disease:Pathophysiology and neuroimaging

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Parkinson's disease(PD)is a neurodegenerative disease characterized by various motor and non-motor symptoms.The com-plexity of its symptoms suggests that PD is a heterogeneous neurological disorder.Its pathological changes are not limited to the substantia nigra-striatal system,but gradually extending to other regions including the cerebellum.The cerebellum is connected to a wide range of central nervous system regions that form essential neural circuits affected by PD.In addition,altered dopaminergic activity and α-synuclein pathology are found in the cerebellum,further suggesting its role in the PD progression.Furthermore,an increasing evidence obtained from imaging studies has demonstrated that cerebellar structure,functional connectivity,and neural metabolism are altered in PD when compared to healthy controls,as well as among different PD subtypes.This review provides a comprehensive summary of the cerebellar pathophysiology and results from neuroimaging studies related to both motor and non-motor symptoms of PD,highlighting the potential significance of cerebellar assessment in PD diagnosis,differential diagnosis,and disease monitoring.

Parkinson's diseaseCerebellumNeuroimagingPathophysiologyDifferential diagnosisDisease progression

Tao Qiu、Meichen Liu、Xinhui Qiu、Tianbai Li、Weidong Le

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Key Laboratory of Liaoning Province for Research on the Pathogenic Mechanisms of Neurological Diseases,the First Affiliated Hospital,Dalian Medical University,Dalian,Liaoning 116000,China

Center for Clinical and Translational Medicine,Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital,Shanghai 200000,China

National Natural Science Foundation of China to WLNational Natural Science Foundation of China to WLLiaoning Provincial Natural Science Foundation Joint Fund toTLShanghai Pudong New Area Health Commission Clinical Characteristic Discipline Construction Plan to TL

32220103006822715242023-MSLH-029PWYts2021-02

2024

10.1097/CM9.0000000000003248

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(20)