首页|Mortality,morbidity,and care practices for 1750 very low birth weight infants,2016-2021

Mortality,morbidity,and care practices for 1750 very low birth weight infants,2016-2021

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  • 国家科技期刊平台
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Background:Very low birth weight(VLBW)infants are the key populations in neonatology,wherein morbidity and mortality remain major challenges.The study aimed to analyze the clinical characteristics of VLBW infants.Methods:A retrospective cohort study was conducted in West China Second Hospital between January 2016 and December 2021.Neonates with a birth weight of＜1500 g were included.Mortality,care practices,and major morbidities were analyzed,and compared with those of previous 7 years(2009-2015).Results:Of the total 1750 VLBW,1386 were infants born with birth weight between 1000-1499 g and 364 infants were born with weight below 1000 g;42.9％(751/1750)required delivery room resuscitation;53.9％(943/1750)received non-invasive ventilation only;38.2％(669/1750)received invasive ventilation;1517 VLBW infants received complete treatment.Among them,60.1％(912/1517)of neonates had neonatal respiratory distress syndrome(NRDS),28.7％(436/1517)had bronchopulmo-nary dysplasia(BPD),22.0％(334/1517)had apnea,11.1％(169/1517)had culture-confirmed sepsis,8.4％(128/1517)had pulmonary hemorrhage,7.6％(116/1517)had severe intraventricular hemorrhage(IVH)/periventricular leukomalacia(PVL),5.7％(87/1517)had necrotizing enterocolitis(NEC),and 2.0％(31/1517)had severe retinopathy of prematurity.The total and in-hospital mortality rates were 9.7％(169/1750)and 3.0％(45/1517),respectively.The top three diagnoses of death among those who had received complete treatment were sepsis,NRDS,and NEC.In 2009-2015,1146 VLBW were enrolled and 895 infants received complete treatment.The proportions of apnea,IVH,and IVH stage ≥3/PVL,were higher in 2009-2015 compared with those in 2016-2021,while the proportions of NRDS and BPD were characterized by significant increases in 2016-2021.The total and in-hospital mortality rates were 16.7％(191/1146)and 5.6％(50/895)respectively in 2009-2015.Conclusion:Among VLBW infants born in 2016-2021,the total and in-hospital mortality rates were lower than those of neonates born in 2009-2015.Incidences of NRDS and BPD increased in 2016-2021,which affected the survival rates and long-term prognosis of VLBW.

MorbidityMortalityVery low birth weightBronchopulmonary dysplasiaRespiratory distress syndromeNewborn

Yang He、Meng Zhang、Jun Tang、Wanxiu Liu、Yong Hu、Jing Shi、Hua Wang、Tao Xiong、Li Zhang、Junjie Ying、Dezhi Mu

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Department of Neonatology,West China Second Hospital,Sichuan University,Chengdu,Sichuan 610041,China

Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu,Sichuan 610041,China

National Key Research &Development Program of ChinaNational Key Research &Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFundamental Research Funds for the Central University

2021YFC27017002021YFC2701704821717108227174982201905SCU2022D006

2024

10.1097/CM9.0000000000002923

中华医学杂志(英文版)
中华医学会

中华医学杂志(英文版)

CSTPCD
影响因子：0.838
ISSN：0366-6999
年,卷(期)：2024.137(20)