Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs,Chaoyang District,Beijing 100021,China

Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital),Qingdao,Shandong 266033,China

Department of Pathology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Chaoyang District,Beijing 100021,China

Department of Laboratory Medicine,ZhuJiang Hospital of Southern Medical University,Guangzhou,Guangdong 510280,China

Department of Medical Oncology,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China

Center of Biotherapy,Beijing Hospital,National Center of Gerontology

Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Graduate School of Peking Union Medical College,Beijing 100730,China

Medical School,University of Chinese Academy of Sciences,Beijing 100049,China