首页|Vascular cognitive impairment:Advances in clinical research and management
Vascular cognitive impairment:Advances in clinical research and management
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国家科技期刊平台
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NSTL
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Vascular cognitive impairment(VCI)encompasses a wide spectrum of cognitive disorders,ranging from mild cognitive impair-ment to vascular dementia.Its diagnosis relies on thorough clinical evaluations and neuroimaging.VCI predominately arises from vascular risk factors(VRFs)and cerebrovascular disease,either independently or in conjunction with neurodegeneration.Growing evidence underscores the prevalence of VRFs,highlighting their potential for early prediction of cognitive impairment and dementia in later life.The precise mechanisms linking vascular pathologies to cognitive deficits remain elusive.Chronic cerebrovascular pathology is the most common neuropathological feature of VCI,often interacting synergistically with neu-rodegenerative processes.Current research efforts are focused on developing and validating reliable biomarkers to unravel the etiology of vascular brain changes in VCI.The collaborative integration of these biomarkers into clinical practice,alongside routine incorporation into neuropathological assessments,presents a promising strategy for predicting and stratifying VCI.The cornerstone of VCI prevention remains the control of VRFs,which includes multi-domain lifestyle modifications.Identifying appropriate pharmacological approaches is also of paramount importance.In this review,we synthesize recent advancements in the field of VCI,including its definition,determinants of vascular risk,pathophysiology,neuroimaging and fluid-correlated biomarkers,predictive methodologies,and current intervention strategies.Increasingly evident is the notion that more rigorous research for VCI,which arises from a complex interplay of physiological events,is still needed to pave the way for better clinical outcomes and enhanced quality of life for affected individuals.
Vascular cognitive impairmentVascular risk factorsCerebral small vessel diseaseStrokeBiomarkersNeuroimaging
Tongyao You、Yingzhe Wang、Shufen Chen、Qiang Dong、Jintai Yu、Mei Cui
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Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China
Department of Neurology,Huashan Hospital,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Fudan University,Shanghai 200040,China
National Center for Neurological Disorders,Huashan Hospital,Fudan University,Shanghai 200040,China
国家科技期刊平台
NSTL
万方数据
