组织工程骨血管化在大段骨缺损治疗中的应用研究进展
Advances in research of tissue engineering bone vascularization in treating large bone defects
姜昊 1陈晓 1苏佳灿1
作者信息
- 1. 200433上海,海军军医大学附属长海医院创伤骨科
- 折叠
摘要
组织工程骨在大段骨缺损的治疗中已由动物实验研究逐渐转向临床应用,并且显示出广阔的前景.在治疗大段骨缺损的研究中,植入物的血供对成骨效果稳定性作用至关重要,因此组织工程骨血管化已成为骨组织工程治疗骨缺损的研究重点.笔者从组织工程骨构建、预制血管技术及细胞技术三个方面对组织工程骨血管化在大段骨缺损治疗中的应用研究进展进行综述,为大段骨缺损的临床治疗提供参考.
Abstract
In recent years,the research on tissue engineering bone in the treatment of large bone defects has shifted from animal experiments to clinical application,showing broad prospect.The blood supply of the implant plays a critical role in the osteogenic stability,so vascularization of tissue engineering bone has become the research focus of bone tissue engineering in the treatment of bone defects.Therefore,the author reviews the research progress of tissue engineering bone vascularization in treatment of large bone defect from the aspects of tissue engineering bone construction,prefabricated vascular technology,and cell technology so as to provide reference for the clinical treatment.
关键词
组织工程/血管/大段骨缺损Key words
Tissue engineering/Blood vessels/Large bone defects引用本文复制引用
基金项目
国家自然科学基金(81701364)
国家自然科学基金(81771491)
国家自然科学基金重大研究计划(91749204)
上海市卫计委优秀学科带头人计划(2017BR011)
上海市科委重点项目(15411950600)
出版年
2018
NETL
NSTL
维普
万方数据