重视双膦酸盐在骨质疏松性骨折术后的应用
Attach great importance to postoperative use of bisphosphonate following osteoporotic fracture
智信 1陈晓 1苏佳灿1
作者信息
- 1. 海军军医大学附属长海医院创伤骨科,上海200433
- 折叠
摘要
骨质疏松性骨折致残致死率高,是临床治疗的难点.双膦酸盐是临床上最常用于预防和治疗骨质疏松症的药物,能抑制破骨细胞骨吸收作用,抑制骨改建,维持骨量.近年来基础及临床研究未表明双膦酸盐影响骨折愈合的证据,因此对于确诊骨质疏松性骨折术后患者,应当重视应用双膦酸盐药物,以减少再骨折风险.笔者对骨质疏松性骨折后应用双膦酸盐干预的相关研究进行总结,提出应在骨质疏松性骨折术后使用双膦酸盐进行干预.
Abstract
Osteoporotic fracture is a clinical problem resulting in significant morbidity and mortality.The main treatment for osteoporosis is bisphosphonate therapy.Bisphosphonates can inhibit the bone resorption by osteoclasts,inhibit bone alteration,and maintain bone mass.In recent years,basic and clinical studies have not found evidence that the use of bisphosphonates for the inhibition of fracture healing.Therefore,for the patients with confirmed osteoporotic fracture,bisphosphonate should be used to reduce the risk of re-fracture.The authors summarize the related studies in the bisphosphonate intervention for osteoporotic fracture and recommend postoperative use of bisphosphonate for osteoporotic fracture.
关键词
骨质疏松/骨质疏松性骨折/二膦酸盐类Key words
Osteoporosis/Osteoporotic fractures/Disphosphonates引用本文复制引用
基金项目
国家重点研发计划(2018YFC2001500)
国家自然科学基金重大研究计划重点项目(91749204)
国家自然科学基金面上项目(81771491)
出版年
2020
NETL
NSTL
维普
万方数据