In recent years,advancements in microfabrication technology and tissue engineering have propelled the development of a novel platform known as organoid-on-a-chip for drug screening and disease modeling.This platform integrates organoids and organ-on-a-chip technologies,emerging as a promising approach for in vitro modeling of human organs.Organ-on-a-chip leverages microfluidic device to simulate the physiological environment of specific organs,offering a more dynamic and flexible setting that can mimic a more comprehensive human biological context.However,the lack of functional vasculature has remained a major challenge in this technology.Vascularization is crucial for the long-term cultivation and in vitro modeling of organoids,which is of great significance in drug development and personalized medical approaches.The authors reviewed the research progress in the construction of vascularized organoid-on-a-chip including the methods for constructing in vitro vascularized models,vascularization of organoids,etc,which may serve as a reference for the construction of fully functional vascularized organoid-on-a-chip.
维普
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