Large skin defect caused by severe trauma is a common clinical problem with high incidence,great harm,difficult treatment and poor prognosis,which not only seriously affects the quality of patients'life,but also threatens their lives.Large skin defects are difficult to heal by themselves and the main treatment is skin transplantation.However,the source of the autologous flap is limited and may cause secondary damage to patients.The artificial skin has poor mechanical integrity that cannot be integrated,causing formation of scars,and also has the risk of immune rejection.Skin organoid technology can extremely simulate the human skin tissue and its functions.Thus,it can overcome the shortcomings of the current skin wound treatment to a certain extent and provide a new treatment for the patients with large skin defects.At present,the construction methods of skin organoids are relatively mature,but each method has its advantages and disadvantages,and the best method has not been determined yet.Moreover,the structure and function of skin organoids are relatively simple,so there is still a relatively big gap between skin organoids and real human skin.Hence,the authors reviewed the research progress in skin organoid construction strategies from organoids'skin organoid technology,and construction methods of skin organoids,hoping to provide a reference for the construction of skin organoids with more complex structures and functions in the future.
维普
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