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肌腱病疼痛发生机制研究进展

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肌腱在运动系统中发挥重要作用,但这一结构损伤后会导致疼痛和功能下降,被称为肌腱病,其中疼痛是最早出现的症状,严重影响患者的生活和工作.尽管目前有多种方法用于治疗肌腱病疼痛,但治疗周期长且效果不佳,其主要原因在于肌腱病疼痛发生机制仍尚未完全明确.因此,明确肌腱病疼痛的发生机制,对寻找新的治疗策略有重要价值.为此,笔者从组织结构改变、疼痛介质、中枢调控等方面就肌腱病疼痛发生机制的研究进展进行综述,为肌腱病疼痛的机制研究和临床治疗提供参考.
Pain mechanism in tendinopathy:a review
Tendons play a crucial role in the motor system.However,tendon injuries can result in pain and function decline,a condition known as tendinopathy.Pain is often the earliest symptom,significantly impacting the lives and work of patients.There are many methods for addressing tendinopathy-associated pain,but the treatment is lengthy and the outcomes are not satisfactory.The main cause is that the mechanism of tendinopathy-associated pain is not completely clear yet.Therefore,it is of great value to identify the mechanism of tendinopathy-associated pain in order to discover new therapeutic strategies.To this end,the authors reviewed the research progress in the mechanisms of tendinopathy-associated pain,including changes in tissue structure,pain mediators,central regulation,etc,to provide a reference for researches on the mechanisms and clinical treatment of tendinopathy-associated pain.

TendinopathySport injuriesPainCentral plasticity

熊英宏、刘申、徐大启

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中南大学湘雅医院运动医学科,湖南省器官损伤衰老与再生医学重点实验室,国家老年疾病临床医学研究中心,长沙 410008

肌腱病 运动损伤 疼痛 中枢可塑性

国家自然科学基金湖南省自然科学基金

819743382023JJ30957

2024

中华创伤杂志
中华医学会

中华创伤杂志

CSTPCD北大核心
影响因子:1.425
ISSN:1001-8050
年,卷(期):2024.40(1)
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