Tendons play a crucial role in the motor system.However,tendon injuries can result in pain and function decline,a condition known as tendinopathy.Pain is often the earliest symptom,significantly impacting the lives and work of patients.There are many methods for addressing tendinopathy-associated pain,but the treatment is lengthy and the outcomes are not satisfactory.The main cause is that the mechanism of tendinopathy-associated pain is not completely clear yet.Therefore,it is of great value to identify the mechanism of tendinopathy-associated pain in order to discover new therapeutic strategies.To this end,the authors reviewed the research progress in the mechanisms of tendinopathy-associated pain,including changes in tissue structure,pain mediators,central regulation,etc,to provide a reference for researches on the mechanisms and clinical treatment of tendinopathy-associated pain.