Application of intracranial pressure-related parameters in predicting the prognosis of severe traumatic brain injury:a review
Patients with severe traumatic brain injury(sTBI)are often combined with intracranial hematoma,hydrocephalus,etc.as well as severe systematic complications such as multiple organ dysfunction and acute respiratory distress syndrome.Currently,intracranial pressure is considered as the most important goal-directed parameter in the clinical management of sTBI,with which a real-time monitoring of the progression of intracranial diseases can be conducted,so as to minimize the incidence of complications such as secondary brain injury.However,intracranial pressure monitoring alone has some limitations,such as incomplete information of intracranial pressure data and lagged information.In addition to intracranial pressure,other intracranial pressure-related parameters are often required for assisting comprehensive monitoring in the clinical settings,including pressure reactivity index(PRx),mean intracranial pressure waveform amplitude(MWA),relationship between waveform amplitude and intracranial pressure(RAP),intracranial aortic amplitude correlation(IAAC),etc.By accurately reflecting cerebral compliance and cerebrovascular autoregulation ability,etc,it can further assist in guiding sTBI treatment strategies and assessing patients'prognosis.However,there is a lack of a comprehensive understanding of intracranial pressure-related parameters in the clinical settings.For this purpose,the authors reviewed the research progress on the application of intracranial pressure-related parameters in predicting the prognosis of sTBI to provide a reference for its clinical application and future research.
Craniocerebral traumaIntracranial pressureCerebrovascular circulationCompliancePressure reactivity index
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