Role of multi-omics technology in elucidating the pathogenesis of post-traumatic sepsis:a review
Sepsis is a syndrome of systemic inflammatory response in which the body's response to infection is dysregulated,and is characterized by persistent infection,excessive inflammation and immunosuppression,etc.It often leads to organ dysfunction and can be life threatening,and also a common complication after trauma.The pathogenesis of post-traumatic sepsis is still unclear at present due to the complexity of its etiology,progression and prognosis.Multi-omics technology is a method to combine two or more single omics for comprehensive analysis,which can reveal the interaction network among the disease-associated molecules from multiple perspectives and aspects and is of great significance for the analysis of the pathogenesis of post-traumatic sepsis.To this end,the authors reviewed the research progress on the role of multi-omics technology in elucidating the pathogenesis of post-traumatic sepsis from the perspectives of genomics,transcriptomics,proteomics,metabolomics,single-cell transcriptomics and combination of multi-omics technologies,etc so as to provide a reference for the researches on post-traumatic sepsis.
Wounds and injuriesSepsisGenomicsProteomicsPathogenesis
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