Preconditioning strategies for mesenchymal stem cells and their application in repair of spinal cord injury:a review
Spinal cord injury is a severe central nervous system injury that may result in partial or complete loss of sensory and motor function.Its treatment methods include laminotomy decompression,high-dose intravenous injection of methylprednisolone,etc.,but their efficacy is not satisfactory.Mesenchymal stem cells(MSCs)are promising in treating spinal cord injury due to their plasticity,low immunogenicity,strong paracrine ability and multi-directional differentiation ability,but problems still exist such as low survival rate,low directional migration ability and unpredictable cell differentiation after transplantation.The strategies for preconditioning MSCs in vitro to enhance their efficacy through gene overexpression,stimulation by physicochemical factors,three-dimensional culture,and cell pre-differentiation have been applied in several studies upon repair of spinal cord injury,but there is no complete summary at present.The authors reviewed these preconditioning strategies for MSCs and the related research progress in spinal cord injury repair so as to provide a reference for the basic research and clinical treatment.
NETL
NSTL
万方数据
