Tendon-bone interface mechanomedicine and its value in the clinical diagnosis and treatment of tendon-bone interface injuries
The tendon-bone interface is where the tendons or ligaments are connected with the bones.A spectrum of injuries may happen to the"soft-to-hard"tissue interface,including those to the rotator cuff-bone and cruciate ligament-bone interfaces,which are often precipitated by a combination of degenerative changes on the tendon-bone interface and acute or chronic injuries,thus severely impairing the patients'motor function.In recent years,with the deepening of the interdisciplinary researches in biomechanics,mechanobiology,and sports medicine,the role of mechanical factors in the repair of tendon-bone interface injuries has attracted more and more attention and becomes a focus of the edge-cutting researches on the tendon-bone interface injuries.To this end,the authors proposed the concept of"tendon-bone interface mechanomedicine"based on an overview of the relevant researches at home and abroad.The mechanical properties of the tendon-bone interface and the effects of mechanical stimuli on its biological behavior were elucidated from the four aspects:biomechanics,mechanobiology,mechanodiagnostics,and mcchanotherapy,aiming to explore the diagnostic and therapeutic strategies for tendon-bone interface injuries from the angle of mechanics and provide new perspectives and methodologies for the field of tendon-bone interface injury repair.
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