首页|The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells

The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells

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Programmed cell death 1 ligand 1(PD-L1)is an important immunosuppressive molecule,which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell death-1.The PD-L1 expression disorder plays an important role in the occurrence,development,and treatment of sepsis or other inflammatory diseases,and has become an important target for the treatment of these diseases.Mesenchymal stem cells(MSCs)are a kind of pluripotent stem cells with multiple differenti-ation potential.In recent years,MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune diseases.Moreover,PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various diseases.In this review,we will summarize the main regulatory mechanism of PD-L1 expression,and discuss various biological functions of PD-L1 in the immune regulation of MSCs.

PD-L1MSCsImmunomodulation

Zhuo Chen、Meng-Wei Yao、Xiang Ao、Qing-Jia Gong、Yi Yang、Jin-Xia Liu、Qi-Zhou Lian、Xiang Xu、Ling-Jing Zuo

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Department of Stem Cell & Regenerative Medicine,State Key Laboratory of Trauma,Burn and Combined Injury,Daping Hospital,Army Medical University,Chongqing,400042,China

College of Basic Medical Sciences,Army Medical University,Chongqing,400038,China

Department of Orthopedics,953 Hospital of PLA,Shigatse Branch of Xinqiao Hospital,Army Medical University,Shigatse,857000,Tibet Autonomous Region,China

Department of Rheumatology and Immunology,Daping Hospital,Army Medical University,Chongqing,400042,China

Department of Obstetrics and Gynecology,Chongqing People's Hospital,Chongqing,401121,China

Department of Medicine,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,China

Department of Nuclear Medicine,The First People's Hospital of Yunnan province,Affiliated Hospital of Kunming University of Science and Technology,Kunming,650034,China

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general project of Chongqing natural science foundationkey project of science and technology in ChongqingNational Natural Science Foundation of China

cstc2021jcyjmsxmX1017CSTC2021jscxgksb-N002632100643

2024

10.1016/j.cjtee.2023.11.003

中华创伤杂志(英文版)
中华医学会

中华创伤杂志(英文版)

CSTPCD
影响因子：0.608
ISSN：1008-1275
年,卷(期)：2024.27(1)
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