中华创伤杂志(英文版)2024，Vol.27Issue(1) ：1-10.DOI:10.1016/j.cjtee.2023.11.003

The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells

Zhuo Chen Meng-Wei Yao Xiang Ao Qing-Jia Gong Yi Yang Jin-Xia Liu Qi-Zhou Lian Xiang Xu Ling-Jing Zuo
中华创伤杂志(英文版)2024，Vol.27Issue(1) ：1-10.DOI:10.1016/j.cjtee.2023.11.003
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The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells

Zhuo Chen 1Meng-Wei Yao 2Xiang Ao 3Qing-Jia Gong 4Yi Yang 5Jin-Xia Liu 6Qi-Zhou Lian 7Xiang Xu 2Ling-Jing Zuo8
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作者信息

  • 1. Department of Stem Cell & Regenerative Medicine,State Key Laboratory of Trauma,Burn and Combined Injury,Daping Hospital,Army Medical University,Chongqing,400042,China;College of Basic Medical Sciences,Army Medical University,Chongqing,400038,China
  • 2. Department of Stem Cell & Regenerative Medicine,State Key Laboratory of Trauma,Burn and Combined Injury,Daping Hospital,Army Medical University,Chongqing,400042,China
  • 3. Department of Orthopedics,953 Hospital of PLA,Shigatse Branch of Xinqiao Hospital,Army Medical University,Shigatse,857000,Tibet Autonomous Region,China
  • 4. College of Basic Medical Sciences,Army Medical University,Chongqing,400038,China
  • 5. Department of Rheumatology and Immunology,Daping Hospital,Army Medical University,Chongqing,400042,China
  • 6. Department of Obstetrics and Gynecology,Chongqing People's Hospital,Chongqing,401121,China
  • 7. Department of Medicine,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,China
  • 8. Department of Nuclear Medicine,The First People's Hospital of Yunnan province,Affiliated Hospital of Kunming University of Science and Technology,Kunming,650034,China
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Abstract

Programmed cell death 1 ligand 1(PD-L1)is an important immunosuppressive molecule,which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell death-1.The PD-L1 expression disorder plays an important role in the occurrence,development,and treatment of sepsis or other inflammatory diseases,and has become an important target for the treatment of these diseases.Mesenchymal stem cells(MSCs)are a kind of pluripotent stem cells with multiple differenti-ation potential.In recent years,MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune diseases.Moreover,PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various diseases.In this review,we will summarize the main regulatory mechanism of PD-L1 expression,and discuss various biological functions of PD-L1 in the immune regulation of MSCs.

Key words

PD-L1/MSCs/Immunomodulation

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基金项目

general project of Chongqing natural science foundation(cstc2021jcyjmsxmX1017)

key project of science and technology in Chongqing(CSTC2021jscxgksb-N0026)

National Natural Science Foundation of China(32100643)

出版年

2024
中华创伤杂志(英文版)
中华医学会

中华创伤杂志(英文版)

CSTPCDCSCD
影响因子：0.608
ISSN：1008-1275
参考文献量154
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