首页|Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury

Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury

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  • NETL
  • NSTL
  • 万方数据
Purpose:Acute kidney injury(AKI)is one of the most common functional injuries observed in trauma patients.However,certain trauma medications may exacerbate renal injury.Therefore,the early detection of trauma-related AKI holds paramount importance in improving trauma prognosis.Methods:Qualified datasets were selected from public databases,and common differentially expressed genes related to trauma-induced AKI and hub genes were identified through enrichment analysis and the establishment of protein-protein interaction(PPI)networks.Additionally,the specificity of these hub genes was investigated using the sepsis dataset and conducted a comprehensive literature review to assess their plausibility.The raw data from both datasets were downloaded using R software(version 4.2.1)and processed with the"affy"package19 for correction and normalization.Results:Our analysis revealed 585 upregulated and 629 downregulated differentially expressed genes in the AKI dataset,along with 586 upregulated and 948 downregulated differentially expressed genes in the trauma dataset.Concurrently,the establishment of the PPI network and subsequent topological analysis highlighted key hub genes,including CD44,CD163,TIMP metallopeptidase inhibitor 1,cytochrome b-245 beta chain,versican,membrane spanning 4-domains A4A,mitogen-activated protein kinase 14,and early growth response 1.Notably,their receiver operating characteristic curves displayed areas exceeding 75％,indicating good diagnostic performance.Moreover,our findings postulated a unique molecular mecha-nism underlying trauma-related AKI.Conclusion:This study presents an alternative strategy for the early diagnosis and treatment of trauma-related AKI,based on the identification of potential biomarkers and therapeutic targets.Additionally,this study provides theoretical references for elucidating the mechanisms of trauma-related AKI.

TraumaAcute kidney injuryBioinformatic analysisDifferentially expressed genesBiomarker

Peng Qi、Meng-Jie Huang、Wei Wu、Xue-Wen Ren、Yong-Zhi Zhai、Chen Qiu、Hai-Yan Zhu

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Department of Emergency,First Medical Center of Chinese PLA General Hospital,Beijing,100853,China

Department of Nephrology,First Medical Center of Chinese PLA General Hospital,Beijing,100853,China

Department of Anesthesiology,First Medical Center of Chinese PLA General Hospital,Beijing,100853,China

Department of Orthopedics,Fourth Medical Center of Chinese PLA General Hospital,Beijing,100853,China

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National Key Research and Development Program of the Ministry of Science and TechnologySpecial Program for Military Nursing Innovation and cultivation ProjectSpecial Program for Military Nursing Innovation and cultivation ProjectYoung Elite Scientist Sponsorship Program by CAST

2019YFC01196012021HL0912021HL0752020QNRC001

2024

10.1016/j.cjtee.2024.01.002

中华创伤杂志(英文版)
中华医学会

中华创伤杂志(英文版)

CSTPCD
影响因子：0.608
ISSN：1008-1275
年,卷(期)：2024.27(2)
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