Objectives To explore the clinical characteristics of children with adenoid hypertrophy(AH)and laryngopharyngeal reflux(LPR)by detecting the expression of pepsin in adenoids as a standard for AH with LPR.Methods A total of 190 children who were admitted for surgical treatment due to AH were included in the study.The main clinical symptoms of the patients were recorded,and the degree of adenoid hypertrophy was evaluated.Before the surgery,Reflux Symptom Index(RSI)and Reflux Finding Score(RFS)were used to evaluate the reflux symptoms.After the surgery,pepsin immunohistochemical staining was performed on the adenoid tissue,and according to the staining results,the patients were divided into study group(pepsin staining positive)and control group(pepsin staining negative).SPSS 19.0 software was used for statistical analysis.Quantitative data conforming to normal distribution between the two groups were tested by two-independent sample t test,and quantitative data with skewed distribution were tested by Mann-Whitney U test.Results The positive rate of pepsin staining in the 190 AH patients was 78.4％(149/190).The study group had higher levels of preoperative symptoms such as erythema and/or congestion of the pharynx(2.1±0.7 vs.1.8±0.6,t=2.23),vocal cord edema[1.0(0,1.0)vs.1.0(0,1.0),Z=2.00],diffuse laryngeal edema[0(0,1.0)vs.0(0,0),Z=2.48],posterior commissure hypertrophy[(1.4±0.6 vs.1.1±0.5),t=2.63],and a higher total score on the RFS scale than the control group(6.2±2.7 vs.5.0±2.6,t=2.47),with statistical differences(P＜0.05).The sensitivity and specificity of RFS score in diagnosing AH with LPR were 24.8％and 80.5％,respectively.When RFS＞5 was used as the positive threshold,the sensitivity and specificity of RFS score in diagnosing AH with LPR were 61.1％and 58.5％,respectively.There was a statistical difference in the number of positive cases of RFS score between the study group and the control group(91 vs.17,x2=5.04,P=0.032).Conclusions LPR is common in AH children.Children with AH and LPR have specific performance in electronic laryngoscopy,such as erythema with edema in the pharynx,posterior commissure hypertrophy,and vocal cord edema.
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