Objective To report outcomes of early intratympanic injection of dexamethasone sodium phosphate and triamcinolone acetonide in the treatment of total sudden sensorineural hearing loss(SNHL).Methods A total of 80 eligible cases admitted to the Department of Otolaryngology,Central Hospital of Wuhan,Tongji Medical College,Hua-zhong University of Science and Technology from January 2020 to January 2022 were retrospective reviewed.These cases were divided into a study group and a control group(40 each)based on their treatment.In addition to routine treat-ments including pro-microcirculation agents,neurotropic agents and thrombolysis agents,cases in the control group re-ceived endoscopic intratympanic injection of dexamethasone,while those in the study group received 4 doses of intra-tympanic injection of triamcinolone acetonide.Overall efficacy,improvement of accompanying symptoms,and changes in hearing were compared between the two groups.Results The rate of overall effectiveness in the study group was higher than that in the control group(P＜0.05).There was no significant difference in improvement of tinnitus,vertigo and ear fullness(P＞0.05).Both groups demonstrated improvement in average hearing threshold at all frequencies,with more noticeable improvements observed in middle and low frequencies.The improvement at 500,1000,and 2000 Hz in the study group was significantly greater than that in the control group(P＜0.001).Conclusion Systemic therapy com-bined with early intratympanic injection of triamcinolone acetonide can improve outcomes in sudden SNHL,and may be worth of clinical adoption.
维普
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