首页|Eph/ephrin信号通路在耳鼻咽喉头颈疾病中的研究进展

Eph/ephrin信号通路在耳鼻咽喉头颈疾病中的研究进展

Progress of Research on Eph/ephrin signaling pathway in otolaryngological diseases

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促红细胞生成素肝细胞激酶受体及其膜结合配体(Eph/ephrin)信号通路是一种受体酪氨酸激酶信号通路,参与机体炎症、癌症进展、肿瘤血管生成、肠道环境稳定、免疫应答、肿瘤免疫、神经发育、损伤后神经再生抑制等多种病理生理机制.Eph/ephrin在听觉神经发育、听觉系统回路和拓扑结构的形成,慢性鼻窦炎的发展以及头颈肿瘤的侵袭、转移、复发和治疗中发挥核心作用,有可能成为耳鼻咽喉头颈疾病的诊断、预后指标和治疗的重要靶点,本研究就Eph/ephrin信号通路在耳鼻咽喉头颈疾病中作用的研究进展进行综述.
Erythropoietin-producing hepatocellular receptors and their receptor-interacting proteins(Eph/ephrin),a receptor tyrosine kinase signaling pathway,are involved in multiple cellular pathophysiological and physiological mechanisms such as inflammation,cancer progression,tumor angiogenesis,intestinal environmental stability,immune response,tumor immunity,neural development,and inhibition of nerve regeneration after injury.Eph/ephrin signaling plays a core role in the development of auditory nerves,the formation of auditory system circuits and topological struc-tures,the development of chronic sinusitis,and the invasion,metastasis and treatment response in head and neck tumors.It may become a diagnostic indicator,a prognostic indicator,and an important therapeutic target in otolaryngological dis-eases.This study mainly reviews the roles of the Eph/ephrin signaling pathway in otolaryngological diseases.

Erythropoietin-producing hepatocellular receptors and their receptor-interacting proteins(Eph/eph-rin)Auditory systemChronic rhinosinusitisHead and neck Tumor

黄巧、尹时华

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广西医科大学第二附属医院耳鼻咽喉头颈外科(南宁 530007)

促红细胞生成素肝细胞激酶受体及其膜结合配体 听觉系统 慢性鼻窦炎 头颈肿瘤

国家自然科学基金国家自然科学基金广西医科大学青年科学基金资助项目

82160213U22A2022GXMUYSF202345

2024

10.3969/j.issn.1672-2922.2024.03.031

中华耳科学杂志
解放军总医院耳鼻咽喉科研究所

中华耳科学杂志

CSTPCD北大核心
影响因子：0.954
ISSN：1672-2922
年,卷(期)：2024.22(3)