Erythropoietin-producing hepatocellular receptors and their receptor-interacting proteins(Eph/ephrin),a receptor tyrosine kinase signaling pathway,are involved in multiple cellular pathophysiological and physiological mechanisms such as inflammation,cancer progression,tumor angiogenesis,intestinal environmental stability,immune response,tumor immunity,neural development,and inhibition of nerve regeneration after injury.Eph/ephrin signaling plays a core role in the development of auditory nerves,the formation of auditory system circuits and topological struc-tures,the development of chronic sinusitis,and the invasion,metastasis and treatment response in head and neck tumors.It may become a diagnostic indicator,a prognostic indicator,and an important therapeutic target in otolaryngological dis-eases.This study mainly reviews the roles of the Eph/ephrin signaling pathway in otolaryngological diseases.
关键词
促红细胞生成素肝细胞激酶受体及其膜结合配体/听觉系统/慢性鼻窦炎/头颈肿瘤
Key words
Erythropoietin-producing hepatocellular receptors and their receptor-interacting proteins(Eph/eph-rin)/Auditory system/Chronic rhinosinusitis/Head and neck Tumor
维普
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