肿瘤坏死因子-α、超敏C反应蛋白与突发性耳聋关系的Meta分析
A Meta-Analysis of the Relationship Between TNF-α,hs-CRP and Sudden Sensorineural Hearing Loss
米雪芹 1王媛玲 2潘庆春 2徐瑞 2张琪 2胡雯静 2李蓓1
作者信息
- 1. 川北医学院运动医学与康复学院(南充 637000)
- 2. 川北医学院附属医院耳鼻咽喉头颈外科
- 折叠
摘要
目的 利用Meta分析方法分析肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)、超敏C反应蛋白(high sensitivity c-reactive protein,hs-CRP)与突发性耳聋(sudden sensorineural hearing loss,SSNHL)的关系.方法 用计算机检索中国知网、万方数据、维普网、CBM、PubMed、Embase、Cochrane library、Web of Science等中英文数据库,搜集有关TNF-α、hs-CRP与SSNHL相关研究,时间范围为建库起至2022年4月.由2位独立评价者筛选文献、提取资料,采用RevMan5.3软件、Stata软件对符合质量标准的研究进行Meta分析.结果 纳入16篇文献研究,SSNHL患者血清TNF-α、hs-CRP浓度均高于对照组,差异均有统计学意义(P<0.05).结论 SSNHL患者血清TNF-α、hs-CRP升高,对疾病诊疗有一定临床指导价值.
Abstract
Objective To systematically evaluate the relationship between tumor necrosis factor-alpha(TNF-α),high sensitivity C-reactive protein(hs-CRP)and sudden sensorineural hearing loss(SSHL).Methods Both English and Chinese language databases including CNKI,WanFang,VIP,China Biomedical Literature Database(CBM),Embase,Pubmed,the Cochrane Library and Web of Science were searched for studies on TNF-α and hs-CRP related to SSHL published up to April 2022.Two independent reviewers screened the results and extracted the data.The RevMan5.3 and Stata software were used for meta-analysis of studies that met the quality standards.Results Sixteen studies were in-cluded.Serum levels of TNF-α and hs-CRP in patients with SSHL were higher than those in the control group(P<0.05).Conclusion Serum levels of TNF-α and hs-CRP in patients with SSHL are elevated and may have certain value-si for guiding the clinical diagnosis and treatment of SSHL.
关键词
突发性耳聋/炎症因子/肿瘤坏死因子-α/超敏C反应蛋白/Meta分析Key words
sudden sensorineural hearing loss/inflammatory factors/tumor necrosic factor-alpha/high sensitivi-ty c-reactive protein/Meta-analysis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据