衰老耳蜗带状突触中的蛋白质稳态
Proteostasis at Ribbon Synapses in Aging Cochlea
蔡玮 1卢春键 2谢慧3
作者信息
- 1. 成都中医药大学附属医院(成都 610072);成都中医药大学;广州中医药大学附属宝安中医院
- 2. 深圳市中医院
- 3. 成都中医药大学附属医院(成都 610072);成都中医药大学
- 折叠
摘要
作为听觉信息转换和传导的关键性传入结构,耳蜗带状突触有着特殊的分子表达,也是耳蜗衰老损伤的早发点.既往研究揭示了蛋白质稳态失衡是衰老改变的重要一环,其在耳蜗衰老中也有突出表现.我们回顾并讨论蛋白质稳态维持的两种主要降解机制,即泛素-蛋白酶系统(ubiquitin-proteasome system,UPS)及自噬-溶酶体途径(autophagy-lysosome pathway,ALP).UPS和ALP是清除错误折叠或未折叠蛋白的关键机制,蛋白质降解机制失调的研究揭示了蛋白质稳态在耳蜗带状突触年龄损伤中的影响.蛋白质平衡的调控可能为年龄相关性听力损伤治疗提供多方面的潜在可能.
Abstract
The cochlear ribbon synapse is a crucial afferent structure for auditory information conversion and con-duction,with special molecular expression.And this synapse has been described as an early-onset point in an aging co-chlea.Previous studies have demonstrated that proteostasis is of great significance to aging changes,also true in cochle-ar aging.In this paper,we provide insights into the two major protein degradation pathways,i.e.the ubiquitin-protea-some system(UPS)and the autophagy-lysosome pathway(ALP),respectively,which are critical mechanisms for clear-ing misfolded or unfolded proteins.Studies on dysregulation of protein degradation mechanisms have revealed the influ-ences of protein homeostasis on synaptic lesions in the aging cochlea.Therefore,regulating protein homeostasis may of-fer considerable and potential possibilities to treat age-related hearing loss.
关键词
耳蜗带状突触/衰老/蛋白质稳态/泛素-蛋白酶系统/自噬-溶酶体途径Key words
cochlear ribbon synapse/aging/proteostasis/ubiquitin-proteasome system/autophagy-lysosome pathway引用本文复制引用
基金项目
四川省科技厅科技创新基地和人才计划项目(2022JD-KP0018)
出版年
2024
国家科技期刊平台
NSTL
万方数据