基于"逆中枢化"理论探讨耳鸣的研究进展
Advances in Studies of Tinnitus from the Aspect of"Inverse Centralisation"
惠渊 1马祺 1周学锐 2高利娜 2张甜 2李妍怡 1巩婷1
作者信息
- 1. 甘肃省中医院(兰州 730050)
- 2. 甘肃中医药大学
- 折叠
摘要
近年来,大量的研究旨在进一步加深我们对耳鸣的发病机制和临床研究的认识,我们首先结合最新的神经生物学机制,系统总结了耳鸣相关中枢增益的证据及潜在机制,认为耳鸣可能是由复杂神经可塑性引起的一种变化,包括病变过程中神经电生理变化、不同神经递质的调控及相关调控基因的改变,其次回顾了临床上基于此理论开发的有效治疗方法,以期为耳鸣的基础研究和临床治疗提供新思路.
Abstract
In recent years,a large number of studies have aimed to further our understanding of tinnitus patho-genesis and clinical research.In this review,evidence of central gain associated with tinnitus and potential mechanisms are summarized from the aspect of the latest knowledge of neurobiological mechanisms.We propose that tinnitus may be a change caused by complex neuroplasticity,including neurophysiological changes in the disease process,modula-tion of different neurotransmitters and alteration of related regulatory genes.This is followed by a review on effective clinical treatments developed based on this theory,to provide new ideas for research and development of clinical treat-ments for tinnitus.
关键词
中枢化/耳鸣/研究进展Key words
inverse centralization/tinnitus/research progress引用本文复制引用
基金项目
联合科研基金一般项目(23JRRA1531)
出版年
2024
国家科技期刊平台
NSTL
万方数据