Neoadjuvant chemoradiotherapy is the standard treatment for patients with locally advanced rectal cancer,which can improve patients'tumor treatment responsiveness and organ preservation rate,and some patients can eventually achieve surgical exemption.Magnetic resonance-guided radiation therapy is a new radiotherapy technique developed in recent years,which can realize adaptive radiotherapy for patients.Moreover,magnetic resonance imaging has better soft-tissue contrast resolution,which helps to better distinguish the tumor from surrounding normal organs.Through magnetic resonance imaging,radiotherapists can observe the tumor and organs at risk during the treatment and make online adjustments to the daily treatment plan according to their anatomical changes.The aim of this article is to explore the potential prospects of application of magnetic resonance guidance in neoadjuvant radiotherapy for rectal cancer.