Current research status of clinical effect of hydromorphone hydrochloride in pediatric postoperative analgesia
Hydromorphone hydrochloride(HM)is a semisynthetic potent opioid analgesic drugs,primarily plays analgesic effect through exciting μ opioid receptors.Because of its unique chemical structure,pharmacodynamics and pharmacokinetics,its physical and chemical properties,analgesic action,as well as safety and effectiveness are better than those of morphine,and is currently widely used for adults.However,research on the analgesic effects of HM in pediatric postoperative analgesia is currently insufficient,and its application is relatively limited.The authors intend to elaborate on the latest research status of the pharmacodynamics and pharmacokinetics of HM,and its clinical application in pediatric postoperative analgesia,aiming to provide references for clinicians to better understand the safety and efficacy of HM in pediatric postoperative analgesia and apply it more effectively in clinical practice.
Hydromorphone hydrochlorideAnalgesics,opioidAnalgesia,epiduralMolecular mechanisms of pharmacological actionPediatric postoperative analgesiaChild
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