摘要
全关节置换术是终末期骨关节病最成功的治疗方法之一。尽管该方法取得了很好的效果，但是磨损颗粒的产生以及随后的生物反应导致无菌性假体松动，仍然是全关节置换失败的最常见原因。信号通路激活是引起假体松动骨溶解的关键因素之一。因此，抑制磨损颗粒介导破骨细胞生成的信号通路，对于治疗骨质疏松和溶骨性病变，防止骨丢失是非常必要的。在本综述中，介绍了磨损颗粒通过多条经典信号通路影响破骨细胞生成及相关靶点的激活或抑制，局部缺氧通过信号通路启动自噬影响破骨细胞骨吸收，以期延缓或避免无菌性松动引起的关节翻修，减轻病人经济和心理负担。
Abstract
Total joint replacement is one of the most successful treatments for end-stage osteoarthrosis. Although this method has achieved good results, the production of wear particles and the subsequent biological reaction which leads to aseptic prosthetic loosening, is still the most common cause of the failure of the total joint replacement. Signal pathway activation is one of the key factors causing osteolysis in prosthetic loosening. Therefore, inhibition of wear particles mediated signal pathway, osteoclast formation in treating osteoporosis and bony lesions, it is necessary to prevent bone loss. This review introduced the wear particles by several classic signaling pathways that affect osteoclast formation and related targets for activation or inhibition, local hypoxia by signaling pathways start autophagy affect osteoclast bone resorption, in order to delay or avoid the cause of aseptic loosening joints was renovated and patients to reduce the economic and psychological burden.
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