摘要
肩袖损伤可由创伤、肩峰下撞击、退变等各种外在或内在因素作用下产生，局部疼痛、功能受限等是肩袖损伤患者的主要症状。目前肩袖损伤通常采取手术修复，术后大部分患者功能得到改善，但修复后组织发生再撕裂概率高。组织工程材料技术出现发展为骨科软组织修复提供了巨大潜力，本文通过回顾临床前研究文献，结合肩袖损伤病理改变，总结常用动物类型及其优缺点，同时分析常见肩袖修补生物材料；旨在为临床前动物研究提供参考，以加快临床研究转化。
Abstract
Rotator cuff injury can be produced by various external or internal factors such as trauma, subacromial impingement, and degeneration. Patients with rotator cuff injuries typically experience local pain and functional limitations. At the moment, rotator cuff injuries are often treated surgically, and the majority of patients experience increased function following surgery, but there is a high risk of the repaired tissue rupturing again. Orthopedic soft tissue restoration has a lot of potential with the development of tissue engineering materials. This article evaluated the preclinical research literature, listed the most often employed animal types, discussed their benefits and drawbacks in relation to the pathological rotator cuff injury alterations, and examined prominent rotator cuff repair biomaterials. In order to hasten the translation of clinical investigations, it intended to serve as a reference for preclinical animal experiments.
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